Public Class Form1
    Private WithEvents Imagen As New System.Windows.Forms.PictureBox

    Private Sub Form1_Load(ByVal sender As System.Object, ByVal e As System.EventArgs) Handles MyBase.Load
        With Imagen
            .Visible = True
            .Top = 0
            .Left = 0
            .Height = 100
            .BackColor = Color.Blue
        End With
        Me.Controls.Add(Imagen)
    End Sub

    Private Sub Imagen_Click(ByVal sender As System.Object, ByVal e As System.EventArgs) Handles Imagen.Click
        MsgBox("hiciste click sobre el picture creado")
    End Sub
End Class